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Cushing's Disease in Dogs

Cushing's disease is a serious condition that can lead to severe, even life-threatening conditions and illnesses in dogs. Today, our Bellevue vets discuss the causes, signs, and treatment options for Cushing's disease in dogs.

Canine Cushing's Disease

Cushing's disease (hyperadrenocorticism) is a serious health condition in which the adrenal glands overproduce cortisol (cortisone) in the body. Excess cortisol can put a dog at risk of several serious conditions and illnesses from kidney damage to diabetes and can be life-threatening to your pooch.

Cushing’s disease is commonly caused by a benign or malignant tumor in the pituitary gland (a pea-sized gland located at the base of the brain). In some cases, the tumor could be located in the adrenal glands, just above the kidneys.

Excessive cortisol can also result from the prolonged use of steroids, called iatrogenic Cushing's syndrome.

Signs of Cushing’s Disease in Dogs

The most common symptoms of Cushing’s disease seen in dogs include:

  • Muscle weakness
  • Enlarged abdomen, potbellied appearance
  • Panting
  • Lethargy
  • Increased appetite
  • Excessive thirst or drinking
  • Frequent urination
  • Hair loss

If your dog has Cushing’s disease you will see at least one of these symptoms, however, it is uncommon for all of these symptoms to be present.

It is essential to contact your vet immediately if your dog is displaying any of the symptoms above. Dogs with Cushing’s disease have an increased risk of diabetes, kidney damage, blood clots, and high blood pressure.

Diagnosing Cushing’s Disease in Dogs

Your vet will do a physical exam and run a few tests to determine what may be causing your pet's symptoms and to rule out other health problems. The tests can include but are not limited to, urinalysis, urine culture, complete blood panel, and/or full chemistry panel.

Your vet may run adrenal function tests, testing adrenal low-dose and high-dose dexamethasone suppression tests. However, adrenal function tests can result in false positives when another disease with similar clinical signs is present.

An ultrasound may help to rule out other conditions that could be causing your dog’s symptoms. Other diseases that may cause similar symptoms include tumors in the spleen or liver, bladder stones, gallbladder disease, gastrointestinal disease, and chronic inflammatory liver disease.

The most effective diagnostic testing for Cushing’s disease is magnetic resonance imaging (MRI) which allows your vet to assess your dog’s adrenal glands. However, this testing method can be expensive.

At Carolina Veterinary Specialists, our vets are trained to diagnose and treat a wide range of internal diseases and conditions. We have access to diagnostic imaging tools and treatment methods to identify and manage these issues.

Treating Cushing’s Disease in Dogs

Cushing's disease in dogs is typically treated with medications that help decrease the amount of cortisone that the adrenal glands produce. The only way to cure Cushing's disease is to remove the tumor, however, because of the complexity and risks of surgery, most cases are treated with medication.

Treatments will vary depending on the type of Cushing’s disease your dog has.

Adrenal tumor: Treatment of an adrenal-dependent Cushing’s disease usually requires major abdominal surgery. If the entire tumor can be removed and the tumor is not malignant, there is a good chance that your dog will regain normal health.

Pituitary tumor: Treatment of pituitary-dependent Cushing’s disease is the most complicated. Two drugs, trilostane, and mitotane are commonly used.

Iatrogenic Cushing’s disease: Treatment requires gradual discontinuation of the steroid, usually resulting in a recurrence of the disease that was being treated by the steroid.

After starting the medication treatments your dog will need to see the vet regularly for ACTH stimulation tests until the excessive production of cortisone is controlled.

Over the lifetime of your pet, routine monitoring of blood tests and medication adjustments need to be made.

Fatality of Cushing's Disease in Dogs

Your dog's prognosis will vary from others as it is dependent on how your pup contracted Cushing's disease in the first place, as well as any other conditions that develop due to the disease. Early diagnosis and treatment are essential for limiting the severity of the disease.

The symptoms of Cushing’s disease can be minimized with diligent observation and long-term management.

Most dogs can be successfully treated with few medication side effects. However, the wrong dose can cause mild or severe side effects. Therefore, your pet must be carefully monitored and follow-up blood tests are essential.

Dogs who do not receive adequate monitoring and follow-up often experience relapses and severe illness or death, as a result of complications.

Note: The advice provided in this post is intended for informational purposes and does not constitute medical advice regarding pets. For an accurate diagnosis of your pet's condition, please make an appointment with your vet.

Is your dog showing signs of Cushing's Disease? Contact our Bellevue vets to book an appointment for your pup

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